How long do I need to be on GLP-1 or GLP-1 GIP therapies to lose 10% of my weight?

Based on clinical trial data, most people using GLP-1 or dual GLP-1/GIP therapies like semaglutide (Wegovy) or tirzepatide (Zepbound) can expect to lose 10% of their body weight within 6 to 9 months, assuming consistent use and appropriate dosing.

Here’s a quick breakdown:

• Semaglutide (GLP-1 only): In the STEP trials, participants lost about 10–15% of their weight over 68 weeks (roughly 16 months), but many reached the 10% mark around 6–9 months in.
• Tirzepatide (GLP-1 + GIP): In the SURMOUNT-1 trial, people lost up to 22.5% of their weight over 72 weeks, with 10% weight loss often achieved by 20–24 weeks (5–6 months).

That said, real-world results can vary. A Cleveland Clinic study found that early discontinuation or lower maintenance doses often led to less weight loss than in trials. So staying on therapy consistently—and working with your provider to manage side effects—can make a big difference.

At BBY Aesthetics, we can help you estimate a timeline based on your current weight and goals, or explore how to support the process with lifestyle tweaks.